Structural highlights
Function
[BEND3_HUMAN] Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity).[UniProtKB:Q6PAL0][1] [2] [ERC6L_HUMAN] DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.[3]
References
- ↑ Sathyan KM, Shen Z, Tripathi V, Prasanth KV, Prasanth SG. A BEN-domain-containing protein associates with heterochromatin and represses transcription. J Cell Sci. 2011 Sep 15;124(Pt 18):3149-63. doi: 10.1242/jcs.086603. PMID:21914818 doi:http://dx.doi.org/10.1242/jcs.086603
- ↑ Khan A, Giri S, Wang Y, Chakraborty A, Ghosh AK, Anantharaman A, Aggarwal V, Sathyan KM, Ha T, Prasanth KV, Prasanth SG. BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8338-43. doi:, 10.1073/pnas.1424705112. Epub 2015 Jun 22. PMID:26100909 doi:http://dx.doi.org/10.1073/pnas.1424705112
- ↑ Baumann C, Korner R, Hofmann K, Nigg EA. PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell. 2007 Jan 12;128(1):101-14. PMID:17218258 doi:http://dx.doi.org/S0092-8674(06)01551-0
