1nih

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Structure of deoxy-quaternary haemoglobin with liganded beta subunits

Overview

We have determined the structure of a T-state haemoglobin in which the, haem groups of the beta subunits have carbon monoxide bound, and the alpha, subunits have nickel replacing the haem iron and are ligand-free. The, structural adjustments on binding ligand in the T state are in the same, direction as those associated with the quaternary transition, and a, translational shift of the haem is severely restricted. We explain how, these observations may account for the low ligand affinity of the beta, haem of T-state haemoglobin.

About this Structure

1NIH is a Protein complex structure of sequences from Homo sapiens with HNI, HEM, CMO and IHP as ligands. Full crystallographic information is available from OCA.

Reference

Structure of deoxy-quaternary haemoglobin with liganded beta subunits., Luisi B, Liddington B, Fermi G, Shibayama N, J Mol Biol. 1990 Jul 5;214(1):7-14. PMID:2370669

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