Structural highlights
5ulp is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , |
| Related: | 5kqr, 5kqs |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 A) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes for the methyl group. We show that the 4-fluorophenyl moiety extends into a portion of the RNA binding tunnel that typically contains the adenosine 2'OH of the RNA-cap moiety. Together, the new SAM analog and the high-resolution crystal structure are a step towards the development of antivirals against ZIKV and other flaviviruses.
Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.,Jain R, Butler KV, Coloma J, Jin J, Aggarwal AK Sci Rep. 2017 May 9;7(1):1632. doi: 10.1038/s41598-017-01756-7. PMID:28487506[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Jain R, Butler KV, Coloma J, Jin J, Aggarwal AK. Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase. Sci Rep. 2017 May 9;7(1):1632. doi: 10.1038/s41598-017-01756-7. PMID:28487506 doi:http://dx.doi.org/10.1038/s41598-017-01756-7
