8ecg

Structural highlights

Function

HMDH1_ARATH Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants.^{[1] [2] [3] [4]}

References

1. ↑ Suzuki M, Kamide Y, Nagata N, Seki H, Ohyama K, Kato H, Masuda K, Sato S, Kato T, Tabata S, Yoshida S, Muranaka T. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. Plant J. 2004 Mar;37(5):750-61. doi: 10.1111/j.1365-313x.2004.02003.x. PMID:14871314 doi:http://dx.doi.org/10.1111/j.1365-313x.2004.02003.x
2. ↑ Ohyama K, Suzuki M, Masuda K, Yoshida S, Muranaka T. Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. Chem Pharm Bull (Tokyo). 2007 Oct;55(10):1518-21. doi: 10.1248/cpb.55.1518. PMID:17917299 doi:http://dx.doi.org/10.1248/cpb.55.1518
3. ↑ Nieto B, Fores O, Arro M, Ferrer A. Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways. Phytochemistry. 2009 Jan;70(1):53-9. doi: 10.1016/j.phytochem.2008.10.010. Epub, 2008 Nov 27. PMID:19041104 doi:http://dx.doi.org/10.1016/j.phytochem.2008.10.010
4. ↑ Suzuki M, Nakagawa S, Kamide Y, Kobayashi K, Ohyama K, Hashinokuchi H, Kiuchi R, Saito K, Muranaka T, Nagata N. Complete blockage of the mevalonate pathway results in male gametophyte lethality. J Exp Bot. 2009;60(7):2055-64. doi: 10.1093/jxb/erp073. Epub 2009 Apr 10. PMID:19363204 doi:http://dx.doi.org/10.1093/jxb/erp073