2dxa

Structural highlights

Function

[YBAK_ECOLI] Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs. Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala-tRNA(Pro).^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Ruan B, Soll D. The bacterial YbaK protein is a Cys-tRNAPro and Cys-tRNA Cys deacylase. J Biol Chem. 2005 Jul 8;280(27):25887-91. Epub 2005 May 10. PMID:15886196 doi:http://dx.doi.org/10.1074/jbc.M502174200
2. ↑ Kumar S, Das M, Hadad CM, Musier-Forsyth K. Aminoacyl-tRNA substrate and enzyme backbone atoms contribute to translational quality control by YbaK. J Phys Chem B. 2013 Apr 25;117(16):4521-7. doi: 10.1021/jp308628y. Epub 2012 Dec , 6. PMID:23185990 doi:http://dx.doi.org/10.1021/jp308628y