Structural highlights
Function
[NTPA_PYRHO] Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (Probable).[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Lokanath NK, Pampa KJ, Takio K, Kunishima N. Structures of dimeric nonstandard nucleotide triphosphate pyrophosphatase from Pyrococcus horikoshii OT3: functional significance of interprotomer conformational changes. J Mol Biol. 2008 Jan 25;375(4):1013-25. Epub 2007 Nov 13. PMID:18062990 doi:10.1016/j.jmb.2007.11.018
