8edc

Structural highlights

Function

UNC5_CAEEL Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756, PubMed:9473333). Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756, PubMed:9473333). Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279, PubMed:17716643).^{[1] [2] [3] [4] [5] [6] [7]}

References

1. ↑ Su M, Merz DC, Killeen MT, Zhou Y, Zheng H, Kramer JM, Hedgecock EM, Culotti JG. Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans. Development. 2000 Feb;127(3):585-94. PMID:10631179
2. ↑ Merz DC, Zheng H, Killeen MT, Krizus A, Culotti JG. Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo. Genetics. 2001 Jul;158(3):1071-80. PMID:11454756
3. ↑ Leung-Hagesteijn C, Spence AM, Stern BD, Zhou Y, Su MW, Hedgecock EM, Culotti JG. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell. 1992 Oct 16;71(2):289-99. PMID:1384987
4. ↑ Zheng H, Coudiere L, Camia C, Colavita A, Culotti JG, Merz DC. C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues. Dev Biol. 2007 Oct 1;310(1):44-53. doi: 10.1016/j.ydbio.2007.07.014. Epub 2007 , Jul 24. PMID:17716643 doi:http://dx.doi.org/10.1016/j.ydbio.2007.07.014
5. ↑ Levy-Strumpf N, Krizus M, Zheng H, Brown L, Culotti JG. The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. PLoS Genet. 2015 Aug 20;11(8):e1005446. doi: 10.1371/journal.pgen.1005446. , eCollection 2015 Aug. PMID:26292279 doi:http://dx.doi.org/10.1371/journal.pgen.1005446
6. ↑ Hamelin M, Zhou Y, Su MW, Scott IM, Culotti JG. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature. 1993 Jul 22;364(6435):327-30. PMID:8332188 doi:http://dx.doi.org/10.1038/364327a0
7. ↑ Colavita A, Culotti JG. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol. 1998 Feb 1;194(1):72-85. doi: 10.1006/dbio.1997.8790. PMID:9473333 doi:http://dx.doi.org/10.1006/dbio.1997.8790