Structural highlights
Publication Abstract from PubMed
Aj_EasH is a non-heme iron- and alpha-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 A resolution) reported here provides insight into the mechanism of this unusual and complex reaction.
Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis.,Jakubczyk D, Caputi L, Stevenson CE, Lawson DM, O'Connor SE Chem Commun (Camb). 2016 Dec 6;52(99):14306-14309. PMID:27885368[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Jakubczyk D, Caputi L, Stevenson CE, Lawson DM, O'Connor SE. Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis. Chem Commun (Camb). 2016 Dec 6;52(99):14306-14309. PMID:27885368 doi:http://dx.doi.org/10.1039/c6cc08438a
