Structural highlights
3wcy is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Related: | |
| Gene: | Ifar, Ifnar, Ifnar1 (LK3 transgenic mice), Ifb, Ifnb, Ifnb1 (LK3 transgenic mice) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[INAR1_MOUSE] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. [IFNB_MOUSE] Has antiviral, antibacterial and anticancer activities.
See Also
