Structural highlights
Function
CAPSD_LAMBD Assembles to form an icosahedral capsid with a T=7 symmetry. The icosahedral capsid is about 60 nm in diameter and composed of 415 major capsid proteins. The assembly is primed by the interaction between capsid assembly protease and portal dodecamer, and major capsid proteins assemble cooperatively to form the procapsid with the help of capsid scaffolding protein. Major capsid protein forms hexons and pentons of the icosahedron. Viral genomic DNA is packaged into the procapsid through the portal vertex (By similarity). The packaging triggers a dramatic reconfiguration of the capsid shell, expanding from roughly 50nm to 60nm while the capsid thickness decreases. The capsid decoration protein binds the expanded capsid and stabilizes it.[HAMAP-Rule:MF_04133][1] [2] [3]
References
- ↑ Katsura I, Kobayashi H. Structure and inherent properties of the bacteriophage lambda head shell. VII. Molecular design of the form-determining major capsid protein. J Mol Biol. 1990 Jun 5;213(3):503-11. doi: 10.1016/S0022-2836(05)80211-6. PMID:2141087 doi:http://dx.doi.org/10.1016/S0022-2836(05)80211-6
- ↑ Murialdo H, Becker A. Assembly of biologically active proheads of bacteriophage lambda in vitro. Proc Natl Acad Sci U S A. 1977 Mar;74(3):906-10. doi: 10.1073/pnas.74.3.906. PMID:265585 doi:http://dx.doi.org/10.1073/pnas.74.3.906
- ↑ Dokland T, Murialdo H. Structural transitions during maturation of bacteriophage lambda capsids. J Mol Biol. 1993 Oct 20;233(4):682-94. PMID:8411174 doi:http://dx.doi.org/10.1006/jmbi.1993.1545
