Structural highlights
Function
[COPC_CHRVO] ADP-riboxanase effector that inhibits host cell pyroptosis (PubMed:34671164). Acts by mediating arginine ADP-riboxanation of host CASP4/CASP11, blocking CASP4/CASP11 autoprocessing (PubMed:34671164). This prevents CASP4 activation and ability to recognize and cleave GSDMD, thereby inhibiting LPS-induced pyroptosis (PubMed:34671164). ADP-riboxanation takes place in two steps: CopC first catalyzes ADP-ribosylation of target Arg, and then initiates a deamination to remove one N-omega group (By similarity).[UniProtKB:A0A0H2US87][1]
References
- ↑ Li Z, Liu W, Fu J, Cheng S, Xu Y, Wang Z, Liu X, Shi X, Liu Y, Qi X, Liu X, Ding J, Shao F. Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11. Nature. 2021 Nov;599(7884):290-295. doi: 10.1038/s41586-021-04020-1. Epub 2021, Oct 20. PMID:34671164 doi:http://dx.doi.org/10.1038/s41586-021-04020-1
