2yf0

Structural highlights

Function

[MTMR6_HUMAN] Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.^{[1] [2]}

See Also

• Dual specificity phosphatase 3D structures

References

1. ↑ Srivastava S, Li Z, Lin L, Liu G, Ko K, Coetzee WA, Skolnik EY. The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. Mol Cell Biol. 2005 May;25(9):3630-8. PMID:15831468 doi:http://dx.doi.org/10.1128/MCB.25.9.3630-3638.2005
2. ↑ Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. Mol Cell Biol. 2006 Aug;26(15):5595-602. PMID:16847315 doi:http://dx.doi.org/10.1128/MCB.00352-06