Structural highlights
Function
[OSPG_SHIFL] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is a kinase that is involved in down-regulation of the host innate response induced by invasive bacteria. Prevents or at least delays host phospho-NF-kappa-B inhibitor alpha (NFKBIA) degradation. Does not phosphorylate E2 enzymes.[1]
See Also
References
- ↑ Kim DW, Lenzen G, Page AL, Legrain P, Sansonetti PJ, Parsot C. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14046-51. Epub 2005 Sep 14. PMID:16162672 doi:http://dx.doi.org/10.1073/pnas.0504466102
