4c5y

Structural highlights

Function

[OTASE_ASPNC] Carboxypeptidase that catalyzes the release of a C-terminal amino acid with specific catalytic activity for aromatic amino acids such as phenylalanine (PubMed:24947135, PubMed:33647354). Is able to degrade ochratoxin A, one of the five major mycotoxins most harmful to humans and animals that is produced by Aspergillus and Penicillium species and occurs in a wide range of agricultural products (PubMed:24947135).^{[1] [2]}

References

1. ↑ Dobritzsch D, Wang H, Schneider G, Yu S. Structural and functional characterization of ochratoxinase, a novel mycotoxin degrading enzyme. Biochem J. 2014 Jun 20. PMID:24947135 doi:http://dx.doi.org/10.1042/BJ20140382
2. ↑ Xiong K, Liu J, Wang X, Sun B, Zhang Y, Zhao Z, Pei P, Li X. Engineering a carboxypeptidase from Aspergillus niger M00988 by mutation to increase its ability in high Fischer ratio oligopeptide preparation. J Biotechnol. 2021 Mar 20;330:1-8. doi: 10.1016/j.jbiotec.2021.02.015. Epub 2021 , Feb 26. PMID:33647354 doi:http://dx.doi.org/10.1016/j.jbiotec.2021.02.015