| Structural highlights
Function
NTPPA_ECOLI Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP (PubMed:24210219, PubMed:25658941, PubMed:28811554). Can also hydrolyze TTP and the modified nucleotides 5-methyl-UTP (m(5)UTP), pseudo-UTP and 5-methyl-CTP (m(5)CTP). Has weak activity with CTP (PubMed:24210219, PubMed:25658941). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219, PubMed:25658941). Important in maintenance of cell shape (PubMed:25658941).[1] [2] [3]
References
- ↑ Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF. Biochemical and Structural Studies of Conserved Maf Proteins Revealed Nucleotide Pyrophosphatases with a Preference for Modified Nucleotides. Chem Biol. 2013 Oct 22. pii: S1074-5521(13)00347-5. doi:, 10.1016/j.chembiol.2013.09.011. PMID:24210219 doi:http://dx.doi.org/10.1016/j.chembiol.2013.09.011
- ↑ Jin J, Wu R, Zhu J, Yang S, Lei Z, Wang N, Singh VK, Zheng J, Jia Z. Insights into the cellular function of YhdE, a nucleotide pyrophosphatase from Escherichia coli. PLoS One. 2015 Feb 6;10(2):e0117823. doi: 10.1371/journal.pone.0117823. , eCollection 2015. PMID:25658941 doi:http://dx.doi.org/10.1371/journal.pone.0117823
- ↑ Shen Q, Tan H, Xing GW, Zheng J, Jia Z. A new method to investigate the catalytic mechanism of YhdE pyrophosphatase by using a pyrophosphate fluorescence probe. Sci Rep. 2017 Aug 15;7(1):8169. doi: 10.1038/s41598-017-08368-1. PMID:28811554 doi:http://dx.doi.org/10.1038/s41598-017-08368-1
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