6tai

Structural highlights

Function

[PYRE_ECOLI] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity).^[1]

References

1. ↑ Henriksen A, Aghajari N, Jensen KF, Gajhede M. A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase. Biochemistry. 1996 Mar 26;35(12):3803-9. PMID:8620002 doi:http://dx.doi.org/10.1021/bi952226y