7q6d

Structural highlights

Function

[FTSA_ECOLI] Essential cell division protein that assists in the assembly of the Z ring (PubMed:11847116). May serve as the principal membrane anchor for the Z ring (PubMed:15752196). Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL, FtsI and FtsN (PubMed:9282742, PubMed:9495771, PubMed:9603865, PubMed:9882666, PubMed:10027987, PubMed:24750258). Binds ATP (PubMed:11053380).^{[1] [2] [3] [4] [5] [6] [7] [8] [9]}

References

1. ↑ Ghigo JM, Weiss DS, Chen JC, Yarrow JC, Beckwith J. Localization of FtsL to the Escherichia coli septal ring. Mol Microbiol. 1999 Jan;31(2):725-37. doi: 10.1046/j.1365-2958.1999.01213.x. PMID:10027987 doi:http://dx.doi.org/10.1046/j.1365-2958.1999.01213.x
2. ↑ Yim L, Vandenbussche G, Mingorance J, Rueda S, Casanova M, Ruysschaert JM, Vicente M. Role of the carboxy terminus of Escherichia coli FtsA in self-interaction and cell division. J Bacteriol. 2000 Nov;182(22):6366-73. doi: 10.1128/JB.182.22.6366-6373.2000. PMID:11053380 doi:http://dx.doi.org/10.1128/JB.182.22.6366-6373.2000
3. ↑ Pichoff S, Lutkenhaus J. Unique and overlapping roles for ZipA and FtsA in septal ring assembly in Escherichia coli. EMBO J. 2002 Feb 15;21(4):685-93. doi: 10.1093/emboj/21.4.685. PMID:11847116 doi:http://dx.doi.org/10.1093/emboj/21.4.685
4. ↑ Pichoff S, Lutkenhaus J. Tethering the Z ring to the membrane through a conserved membrane targeting sequence in FtsA. Mol Microbiol. 2005 Mar;55(6):1722-34. doi: 10.1111/j.1365-2958.2005.04522.x. PMID:15752196 doi:http://dx.doi.org/10.1111/j.1365-2958.2005.04522.x
5. ↑ Busiek KK, Margolin W. A role for FtsA in SPOR-independent localization of the essential Escherichia coli cell division protein FtsN. Mol Microbiol. 2014 Jun;92(6):1212-26. doi: 10.1111/mmi.12623. Epub 2014 May 8. PMID:24750258 doi:http://dx.doi.org/10.1111/mmi.12623
6. ↑ Addinall SG, Cao C, Lutkenhaus J. FtsN, a late recruit to the septum in Escherichia coli. Mol Microbiol. 1997 Jul;25(2):303-9. doi: 10.1046/j.1365-2958.1997.4641833.x. PMID:9282742 doi:http://dx.doi.org/10.1046/j.1365-2958.1997.4641833.x
7. ↑ Yu XC, Tran AH, Sun Q, Margolin W. Localization of cell division protein FtsK to the Escherichia coli septum and identification of a potential N-terminal targeting domain. J Bacteriol. 1998 Mar;180(5):1296-304. doi: 10.1128/JB.180.5.1296-1304.1998. PMID:9495771 doi:http://dx.doi.org/10.1128/JB.180.5.1296-1304.1998
8. ↑ Wang L, Khattar MK, Donachie WD, Lutkenhaus J. FtsI and FtsW are localized to the septum in Escherichia coli. J Bacteriol. 1998 Jun;180(11):2810-6. doi: 10.1128/JB.180.11.2810-2816.1998. PMID:9603865 doi:http://dx.doi.org/10.1128/JB.180.11.2810-2816.1998
9. ↑ Chen JC, Weiss DS, Ghigo JM, Beckwith J. Septal localization of FtsQ, an essential cell division protein in Escherichia coli. J Bacteriol. 1999 Jan;181(2):521-30. PMID:9882666