Structural highlights
Function
SEMG1_HUMAN Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.[1] Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.[2]
References
- ↑ Mitra A, Richardson RT, O'Rand MG. Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. Biol Reprod. 2010 Mar;82(3):489-96. doi: 10.1095/biolreprod.109.081331. Epub 2009, Nov 4. PMID:19889947 doi:http://dx.doi.org/10.1095/biolreprod.109.081331
- ↑ Mitra A, Richardson RT, O'Rand MG. Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. Biol Reprod. 2010 Mar;82(3):489-96. doi: 10.1095/biolreprod.109.081331. Epub 2009, Nov 4. PMID:19889947 doi:http://dx.doi.org/10.1095/biolreprod.109.081331
