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Tubulin 3D Structures

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Revision as of 11:09, 4 February 2024 by Michal Harel (Talk | contribs)
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3D Structures of Tubulin

Updated on 04-February-2024 - For a general description of the protein see Tubulin {{#tree:id=OrganizedByTopic|openlevels=0|

  • α-tubulin
    • 2e4h – hTUBA C terminal + restin CAP-Gly domain 2 – human
    • 6j4v - hTUBA1B + small vasohibin-binding protein + tubulinyl-Tyr carboxypeptidase
    • 2bto – PdTUBA+thioredoxin 1 – Prosthecobacter dejongeii
  • β-tubulin
    • 7trg, 7ttn, 7tub, 7x0s – hTUB-5 + T-complex proteins – Cryo EM
    • 7ylw – yTUB + T-complex proteins + phosducin-like protein– yeast - Cryo EM
    • 7quq – TUB + TUB domain-containing protein + G2P – Cryo EM
  • α-tubulin + β-tubulin
    • 5n5n – hTUBA-1A+hTUB-3 + GTP + GMPCPP – Cryo EM
    • 6e7b – hTUBA-1B+hTUB-3 + GTP + GMPCPP – Cryo EM
    • 5ij0 – hTUBA-1B+hTUB-3 + GTP + GDP – Cryo EM
    • 5ij9 – hTUBA-1B+hTUB-3 (mutant) + GTP + GDP – Cryo EM
    • 7z6s – hTUBA-1B+hTUB-3 + MATCAP + GTP + GDP – Cryo EM
    • 5n5n – hTUBA-1B+hTUB-5 + GTP + GMPCPP – Cryo EM
    • 6e7c – hTUBA-1B+hTUB-2B + GTP + GMPCPP – Cryo EM
    • 8v2i – hTUBA-1B+hTUB-5 + GTP + GMPCPP – Cryo EM
    • 6i2i – hTUBA-1B +hTUB-5 + GTP + GMPCPP + stabilizer – Cryo EM
    • 7lxb, 7m18, 7m20 - hTUBA+hTUBB + GDP + GTP + drug – Cryo EM
    • 1jff - bTUBA+bTUBB - bovine
    • 6wvr, 6wvl, 6wvm - bTUBA+ bTUBB +GTP + GDP + stabilizer - Cryo EM
    • 3j6f - pTUBA+pTUBB – pig - Cryo EM
    • 3j6e, 7dmz - pTUBA+pTUBB +GMPCPP – Cryo EM
    • 3j7i - pTUBA+pTUBB +GTP – Cryo EM
    • 5xxt, 5xxv, 5xxw, 6dpv, 6ew0, 6evx, 6evz, 6o2r, 6o2q, 6o2s, 6o2t, 7yso, 7ysp - pTUBA+pTUBB +GTP + GDP – Cryo EM
    • 7yhn - pTUBA+pTUBB +GTP + GDP + anti-tumor agent – Cryo EM
    • 6evy, 6dpw - pTUBA+pTUBB + GTPgS + GTP – Cryo EM
    • 5xxx, 7dn0 - pTUBA+pTUBB +GTP + GMPCPP – Cryo EM
    • 6dpu, 6evw, 7ysn - pTUBA+pTUBB + GMPCPP + GTP – Cryo EM
    • 1tub - pTUBA+pTUBB – electron diffraction
    • 7ysq, 7ysr - DmTUBA+TUBB1 + GSP + GTP – Drosophila melanogaster - Cryo EM
    • 7qud - DmTUBA+TUBB1 + GTP - Cryo EM
    • 7quc - DmTUBA+TUBB1 + GDP + GTP - Cryo EM
    • 5w3f, 5w3j - yTUBA+ yTUBB +GTP + GDP - Cryo EM
    • 5w3h - yTUBA+ yTUBB +GTP + GDP + stabilizer - Cryo EM
    • 2btq – PdTUBA+PdTUBB
    • 6e88 - TUBA+ TUBB +GTP + GDP – Caenorhabditis elegans - Cryo EM
    • 6ve7, 6u42 – TUBA + TUBB + GTP + GDP + stabilizer – Chlamydomonas reinhardtii - Cryo EM
    • 6u0h, 5ubq, 5ucy - TtTUBA+TUBB + GTP + GDP – Tetrahymena thermophila - Cryo EM
    • 7miz - TUBA+TUBB + SPM1 + PDI + GTP + GDP – Toxoplasma gondii - Cryo EM
  • α-tubulin + β-tubulin complexes with stathmin
    • 5lp6 – bTUBA1B +bTUBB2B +stathmin-4 + protein
    • 3du7, 3e22, 1z2b, 1sa0, 1sa1, 1ffx – bTUBA1C+bTUBB2B+stathmin-4
    • 8bde, 8bdf, 8bdg – bTUBA1B+bTUBB2B +stathmin-4 + GDP + GTP + chemotherapy agent
    • 7z2n – bTUBA1B+bTUBB2B +stathmin-4 + GDP + GTP + destabillizing agent
    • 5o7a, 5ov7 – bTUBA1B+bTUBB2B +stathmin-4 + GDP + GTP + ACP + destabillizing agent
    • 5la6, 8c0f, 8clh - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ACP + antitumor drug
    • 7jfr - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ACP + auristatin
    • 7zx2, 8a0l - bTUBA+bTUBB+stathmin-4 + protein + GDP + GTP + ACP + pelophen
    • 6xes, 6xet, 7lz7, 7lz8 – pTUBA1B +pTUBB +stathmin-4 + inhibitor
    • 6xer, 8a9t – pTUBA1B +pTUBB +stathmin-4 + inhibitor + GTP + GDP
    • 6ls4, 7ttd, 7tte, 7ttf – pTUBA1B +pTUBB +stathmin-4 + GDP + GTP + anti-tumor agent
    • 3hkb, 3hkc, 3hkd, 3hke, 3n2g, 3n2k, 3ryc, 3ryf, 3ryh, 3ryi, 4eb6 – sTUBA+sTUBB+stathmin-4 – sheep
    • 4f61 - sTUBA+sTUBB+stathmin-like protein R4
    • 3ut5 - sTUBA+sTUBB+stathmin-4 + vinca peptide
    • 4eb6 - sTUBA+sTUBB+stathmin-4
    • 6tde - sTUBA+sTUBB+stathmin-4 + GDP + GTP
    • 6h9b, 6th4 - sTUBA+sTUBB+stathmin-4 + GDP + GTP + inhibitor
    • 6tis , 6tiu, 6tiy, 6tiz– DmTUBA1 (mutant) +TUBB1 (mutant) +stathmin-4 + GDP + GTP
  • α-tubulin + β-tubulin complexes with stathmin and tubulin Tyr-ligase
    • 5ezy - pTUBA+ bTUBB+stathmin-4 + protein + GDP + GTP + ACP + stabilizer
    • 5zxh - pTUBA+ bTUBB (mutant) +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ACP + imidazole derivative
    • 5z4u, 6agk, 5h7o, 5h74 – pTUBA + bTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ACP + inhibitor
    • 5fnv – cTUBA + rTUBB +stathmin-4 + TUB-Tyr ligase + GDP + GTP + ACP + anti-tumor agent - chicken
    • 5ca1 – pTUBA + cTUBB + stathmin-4 + TUB-Tyr ligase + GDP + GTP + ACP + inhibitor
  • α-tubulin + β-tubulin complex with kinesin
    • 2p4n - hTUBA+hTUBB+kinesin heavy chain
    • 6ojq – hTUBA1B+hTUBB2B+kinesin -1 heavy chain + GTP + GMPCPP – Cryo EM
    • 2wbe – bTUBA1D+bTUBB2B+kinesin+AMPPNP
    • 3dco - bTUBA+bTUBB+kinesin-like NOD
    • [4ck5]], 4ck6, 4ck7 - bTUBA+bTUBB+kinesin-like KIF11 motor domain
    • 5hnw, 5hnx, 5hny, 5hnz – bTUBAB1 +bTUBBB2 +kinesin-14 + GDP + GTP + stabilizer
    • [[3edl}} - bTUBA1D+bTUBB2B+kinesin motor domain
    • 4uxo, 4uxp, 4uxr, 4uxs, 4uxy - bTUBA+bTUBB + kinesin motor domain + GDP + GTP + stabilizer – Cryo EM
    • 4uxt, 4uy0 - bTUBA+bTUBB + kinesin heavy chain + GDP + GTP + stabilizer – Cryo EM
    • 3j2u - bTUBA+bTUBB+kinesin-like KLP10A head domain
    • 4aqv, 4aqw - bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM
    • 4atx - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM
    • 6zpi - bTUBA1D+bTUBB2B+kinesin motor domain Kif15 – Cryo EM
    • 5nd3 - bTUBA+bTUBB2B+kinesin-like motor domain Kif20A – Cryo EM
    • 5nd7 - bTUBA+bTUBB2B+kinesin-like motor domain Kif20A + GTP + GDP + ANP – Cryo EM
    • 5nd2, 5nd4 - bTUBA+bTUBB2B+kinesin-like motor domain Kif20A + GTP + GDP + ADP – Cryo EM
    • 5m5i, 5m5l, 5m5m, 5m5n, 5m5o – bTUBA1B + bTUBB2B +kinesin-like protein CUT7 + GTP + GDP + ANP – Cryo EM
    • 5mm7 - bTUBA1A+bTUBB +kinesin-4 motor domain + GTP + GDP + ANP + stabilizer – Cryo EM
    • 5mm4 - bTUBA1A+bTUBB +kinesin-5 motor domain + GTP + GDP + ANP + stabilizer – Cryo EM
    • 5ogc, 5oam - bTUBA+pTUBB+kinesin-like KIF18A + GTP + GDP + stabilizer – Cryo EM
    • 5ocu - bTUBA+pTUBB+kinesin-like KIF18A + GTP + GDP + ANP + stabilizer – Cryo EM
    • 5mio - bTUBA+sTUBB+kinesin-like KIF2C + ANP + GDP + GTP
    • 2hxf - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP
    • 3j6h - pTUBA+pTUBB +GMPCPP + kinesin heavy chain – Cryo EM
    • 3j8x, 7tr2 - pTUBA+pTUBB +GDP + GTP + kinesin heavy chain – Cryo EM
    • 3j8y - pTUBA+pTUBB +GDP + GTP + ATP + kinesin heavy chain – Cryo EM
    • 7tr0 - pTUBA+pTUBB +G2P + GTP + ANP + kinesin-3 – Cryo EM
    • 7z2a, 7z2b, 7z2c - pTUBA+pTUBB +G2P + GTP + kinesin-8 – Cryo EM
    • 2hxh - pTUBA+pTUBB+kinesin-like KIF1A+ADP
    • 1ia0 - pTUBA+pTUBB+kinesin-like KIF1A+ATP
    • 7rx0 - pTUBA+pTUBB+kinesin-like KIF7 + GTP + ANP + G2P
    • 6b0l - pTUBA+pTUBB+kinesin-like 10A+AMPPNP
    • 6tiw - pTUBA+pTUBB+kinesin-like KIF11 + GMPCPP + quinoline derivative – Cryo EM
    • 6ta4 - pTUBA+pTUBB+kinesin-like KIF11 + GTP + GMPCPP + ANP – Cryo EM
    • 6ta3 - pTUBA+pTUBB+kinesin-like KIF11 + GTP + GMPCPP + quinolin derivative – Cryo EM
    • 6wwp, 6wwt - pTUBA+pTUBB+kinesin-like KIF14 + GTP + GDP – Cryo EM
    • 6b0c, 6b0i - pTUBA+pTUBB+kinesin-like KLP10A + GTP + GDP + stabilizer – Cryo EM
    • 6vpp - pTUBA+pTUBB+kinesin-like KLP61F + GTP + GDP – Cryo EM
    • 6vpo - pTUBA+pTUBB+kinesin-like KLP61F + GTP + GDP + ANP – Cryo EM
    • 6mlr - pTUBA+pTUBB+kinesin-like KIF7 + GTP + GDP + ANP + stabilizer – Cryo EM
    • 6mlq - pTUBA+pTUBB+kinesin-like KIF7 + GTP + GDP + ADP + stabilizer – Cryo EM
    • 8f18, 8f1a - pTUBA+pTUBB+kinesin-like KIF20A + GTP + GDP – Cryo EM
    • 6s8m - pTUBA+pTUBB+kinesin-like CUT7 + GTP + GDP + ANP – Cryo EM
    • 7tqz – pTUBA1B +pTUBB2B +kinesin-like protein + GTP + GDP – Cryo EM
    • 7tqy – pTUBA1B +pTUBB2B +kinesin-like protein + GTP + GDP + ADP – Cryo EM
    • 7tqx – pTUBA1B +pTUBB2B +kinesin-like protein + GTP + GDP + ANP – Cryo EM
    • 8ixb – mTUBA1A+mTUBB2A+kinesin -1 heavy chain + GTP + + ATP + GMPCPP – Cryo EM
    • 8ixe, 8ixf – mTUBA1A+mTUBB2A+kinesin -1 heavy chain + GTP + + ATP + G2P – Cryo EM
    • 8ixa, 8ixd – mTUBA1C +mTUBB2A+kinesin -1 heavy chain + GTP + + ATP + G2P – Cryo EM
    • 5mlv - fyTUBA+ fyTUBB+kinesin-like CUT7 + GTP + GDP + ANP – fission yeast - Cryo EM
  • α-tubulin + β-tubulin complex with darpin (Ankyrin repeat protein)
    • 7pjf - hTUBA+hTUBB + darpin + GTP
    • 4f6r - sTUBA+sTUBB+stathmin-like protein R1 + darpin
    • 4hna - bTUBA+bTUBB + kinesin heavy chain + darpin
    • 5nqu, 7yyy, 7yz2, 7yz3, 7yz5 – bTUBA1B+bTUBB2B + darpin + GDP + GTP
    • 7yyq, 7yz6 – bTUBA1B+bTUBB2B + darpin + GTP + drug
    • 7yyv, 7yyw, 7yyx, 7yyz, 7yz0, 7yz1 – bTUBA1B+bTUBB2B + darpin + GDP + GTP + drug
    • 6bbn, 7x4n - pTUBA+pTUBB+kinesin-like KIF2A + darpin + ANP + GDP + GTP
    • 4lnu - sTUBA+sTUBB + darpin + GDP + GTP + kinesin heavy chain
    • 6s8l, 6s8k - hTUBA+hTUBB + darpin + GDP + GTP + plinabulin
    • 8cl9 - bTUBA+bTUBB + darpin + GTP
    • 6zwb, 6zwc - bTUBA+bTUBB + darpin + photoswitch + GTP + GDP
    • 5itz - bTUBA+bTUBB + CENP-J + darpin + GTP + GDP + colchicine
    • 5eib - bTUBA+bTUBB + CENP-J peptide + darpin + GTP + GDP
    • 7ac5 - bTUBA+ bTUBB + stathmin-like domain R1 + darpin + GDP + GTP
    • 6mzg, 6mzf, 6mze - pTUBA+pTUBB + STU2P + darpin + GTP + GDP
    • 6bjc, 6gvn - sTUBA+sTUBB + darpin + GTP
    • 6gvm - sTUBA+sTUBB + stathmin-like domain R1 + darpin + GDP + GTP
    • 4drx - sTUBA+sTUBB + darpin
    • 7pje - TtTUBA+TtTUBB + darpin + GTP
  • α-tubulin + β-tubulin other complexes
    • 6rza - hTUBA+hTUBB +GTP + GDP + stabilizer + dynein heavy chain – Cryo EM
    • 6qvj, 6qus - hTUBA+hTUBB +GTP + GDP + stabilizer + CAMSAP1 – Cryo EM
    • 6qve - hTUBA+hTUBB + GTP + GDP + stabilizer + protein – Cryo EM
    • 6quy - hTUBA+hTUBB +GTP + GDP + stabilizer + CKK – Cryo EM
    • 7zcw - hTUBA1A+hTUBB2B + small vasohibin-binding protein + tubulinyl-Tyr carboxypeptidase + G2P + GTP – Cryo EM
    • 6wsl - hTUBA1A+hTUBB3 + small vasohibin-binding protein + tubulinyl-Tyr carboxypeptidase + GMPCPP + GTP – Cryo EM
    • 7z7d - bTUBA+bTUBB+GDP+GTP+ drug
    • 1tvk - bTUBA+bTUBB+GDP+GTP+ drug – electron crystallography
    • 3iz0 - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy
    • 3j1t, 3j1u - bTUBA+bTUBB+ dynein
    • 4atu - bTUBA1D+bTUBB2B+doublecortin – Cryo EM
    • 6rev, 6rf2, 6rf8, 6rfd - bTUBA1B+bTUBB2B + doublecortin + GDP + GTP – Cryo EM
    • 8ou0 – bTUBA3+bTUBB2C + stabilizer of axonemal microtubules + sperm acrosome associated 9 + GDP + GTP – Cryo EM
    • 5m50, 5m54, 5m5c - bTUBA1B+bTUBB2B + calmodulin-regulated spectrin-associated protein + GDP + GTP – Cryo EM
    • 6kiq, 6kio – pTUBA1A+pTUBB + dynein heavy chain – Cryo EM
    • 7u0f – pTUBA1A+pTUBB +REV – Cryo EM
    • 3j6p, 6rzb - pTUBA+pTUBB +GTP + GDP + stabilizer + dynein heavy chain – Cryo EM
    • 3j6g - pTUBA+pTUBB +GTP + GDP + stabilizer – Cryo EM
    • 5kmg - pTUBA+pTUBB + protein regulator + GTP + GDP – Cryo EM
    • 6cvj, 6cvn – pTUBA1B+pTUBB + tau + GTP + GDP – Cryo EM
    • 5syg, 5syf, 5sye, 5syc - pTUBA+pTUBB + STU2P + stabilizer + GTP + GDP
    • 6gx7 - sTUBA+sTUBB + alpharep + low calcium response + GTP
    • 6gwd, 6gwc - sTUBA+sTUBB + alpharep + GTP + GDP
    • 7q1f, 7z0g - sTUBA+sTUBB + alpharep + CENP-J + GTP + GDP
    • 4ffb, 4u3j - yTUBA+TUBB (mutant) + protein STU2
    • 5mjs - fyTUBA+ fyTUBB + MAL3 + GTP + GDP + ANP - Cryo EM
    • 6u0u, 6u0t - TtTUBA+TUBB+ profilament ribbon protein + GTP + GDP - Cryo EM
    • 7mwg - TtTUBA+TUBB + GTP + GDP - Cryo EM
    • 7n32 - TtTUBA+TtTUBB + dynein + GTP + GDP – Cryo EM

γ-tubulin

3cb2 – hTUBG1+GDP 1z5v - hTUBG1+GTPgS 1z5w - hTUBG1+GTP

    • 6v6b – hTUBG2 + TUBG3 – Cryo EM
    • 6x0v – hTUBG2 + mitotic-spindle organizing protein + Cep215 – Cryo EM

3rip – hTUBG4

    • 6v69 – hTUBG4 + TUBG5 – Cryo EM
    • 6x0u – hTUBG3 + TUBG6 + mitotic spindle organizing protein – Cryo EM
    • 6l81 – hTUBG5 + mitotic-spindle organizing protein
    • 6v6c – hTUBG6 – Cryo EM
    • 6v6s – hTUBG + ADP + GDP – Cryo EM
    • 6tf9 – fTUBG – frog - Cryo EM
    • 7fad – fTUBG 1-163 + mitotic-spindle organizing protein
    • 5fm1, 7m2w, 7m2x, 7m2y, 7m2z – yTUBG + SPC97 + SPC98 - Cryo EM
    • 5flz – yTUBG + SPC97 + SPC98 + SPC110 - Cryo EM
    • 6l80 – fyTUBG subunit Mod21 + mitotic-spindle organizing protein
    • 7anz – TUBG – Candida albicans - Cryo EM

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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