Structural highlights
Publication Abstract from PubMed
The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.
Crystal structure of a four-stranded intercalated DNA: d(C4).,Chen L, Cai L, Zhang X, Rich A Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:7947764[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Chen L, Cai L, Zhang X, Rich A. Crystal structure of a four-stranded intercalated DNA: d(C4). Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:7947764
