Structural highlights
Publication Abstract from PubMed
2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
DNA minor groove interactions and the biological activity of 2,5-bis.,Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S. DNA minor groove interactions and the biological activity of 2,5-bis. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:11128631
