Structural highlights
Publication Abstract from PubMed
DNA has proved to be a versatile material for the rational design and assembly of nanometer scale objects. Here we report the crystal structure of a continuous three-dimensional DNA lattice formed by the self-assembly of a DNA 13-mer. The structure consists of stacked layers of parallel helices with adjacent layers linked through parallel-stranded base pairing. The hexagonal lattice geometry contains solvent channels that appear large enough to allow 3'-linked guest molecules into the crystal. We have successfully used these parallel base pairs to design and produce crystals with greatly enlarged solvent channels. This lattice may have applications as a molecular scaffold for structure determination of guest molecules, as a molecular sieve, or in the assembly of molecular electronics. Predictable non-Watson-Crick base pairs, like those described here, may present a new tool in structural DNA nanotechnology.
Crystal structure of a continuous three-dimensional DNA lattice.,Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC Chem Biol. 2004 Aug;11(8):1119-26. PMID:15324813[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC. Crystal structure of a continuous three-dimensional DNA lattice. Chem Biol. 2004 Aug;11(8):1119-26. PMID:15324813 doi:10.1016/j.chembiol.2004.05.021
