Structural highlights
Publication Abstract from PubMed
DNA oligonucleotides can be used in order to assemble highly structured materials. Oligonucleotides with sticky ends can form long linear structures, whereas branching is required to form two- and three-dimensional nanostructures. In this paper, we show that when Ni(2+) is attached to the N7 atom of guanine, it can also act as a branching point. Thus, we have found that the heptanucleotide d(GAATTCG) can assemble into long linear duplex structures, which cross in space to generate a cubic structure. The three-dimensional arrays are stabilized by phosphate-Ni(2+)-guanine interactions. For the first time, the crystallization of a B form DNA oligonucleotide in a cubic system is reported, space group I23. Large solvent cavities are found among the DNA duplexes.
A cubic arrangement of DNA double helices based on nickel-guanine interactions.,Valls N, Uson I, Gouyette C, Subirana JA J Am Chem Soc. 2004 Jun 30;126(25):7812-6. PMID:15212528[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Valls N, Uson I, Gouyette C, Subirana JA. A cubic arrangement of DNA double helices based on nickel-guanine interactions. J Am Chem Soc. 2004 Jun 30;126(25):7812-6. PMID:15212528 doi:http://dx.doi.org/10.1021/ja049393i
