Tyrosine phosphatase 3D structures

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3D Structures of tyrosine phosphatase

Updated on 15-February-2024 - For a general description of the protein see Tyrosine phosphatase {{#tree:id=OrganizedByTopic|openlevels=0|

• Class I

• Non-receptor type tyrosine phosphatase; Domains – catalytic 1-321;

• • 8u1e - hPTP-1b catalytic domain - human
    
  • 1a5y, 2hnp, 2hnq, 1oem, 1oeo, 1oes, 1oet, 1oeu, 1oev, 1sug, 2cm2, 2cm3, 3eu0, 3i80, [[3a5j, 6ntp, 6xe8, 6xee, 7key, 7l0c, 7lfo, 7rin - hPTP-1b catalytic domain
    
  • 1gfy, 1i57, 1pa1, 2f6f, 3a5k, 3zv2, 3qkp, 6olq, 6olv, 6omy, 6pfw, 6pg0, 6pgt, 6pha, 6phs, 6cwv, 6cwu, 7fre, 7frs, 7frt, 7fru, 7gsc, 7gtw, 7gtx, 7gty, 7gtz, 7gu0, 7gu1, 7gu2, 7gu3, 7gu4, 7gu5, 7gu6, 7gu7, 7gu8, 7gu9, 7gua, 7gub, 7guc, 7ken, 7mkz, 7mn9, 7mnc, 7mou, 7mov, 7s4f, 8du7, 8exi, 8xoy - hPTP-1b catalytic domain (mutant)
  • 3lnx - hPTP-1e PDZ2 domain 1361-1456
    
  • 3pdz, 7qcx - hPTP-1e PDZ2 domain – NMR
    
  • 2m0z - hPTP-1e PDZ2 domain (mutant) – NMR
    
  • 5k9v – hPTPN1 catalytic domain
    
  • 4qah, 4qap, 4qbe, 4qbw, 5kaa, 5ka8, 5ka4, 5ka2, 5ka1, 5ka0 – hPTPN1 catalytic domain (mutant)
    
  • 6zz4, 7f5n, 7f5o – hPTPN2 catalytic domain
    
  • 2b49 – hPTPN3 catalytic domain
    
  • 4qun – hPTPN3 catalytic domain (mutant)
    
  • 2i75 – hPTPN4 611-926
    
  • 2cs5 – hPTPN4 PDZ domain 507-612 – NMR
    
  • 2vph - hPTPN4 PDZ domain
    
  • 2bij, 8sls, 8slt, 8slu – hPTPN5 catalytic domain 258-561
    
  • 2bv5 - hPTPN5 catalytic domain (mutant)
    
  • 1zco, 2a3k – hPTPN7 65-358
    
  • 2gp0, 2hvl, 2qdc, 2qdm, 2qdp, 3o4s, 3o4t, 3o4u – hPTPN7 65-360 (mutant)
    
  • 2pa5 – hPTPN9 catalytic domain 277-582
    
  • 5hde - hPTPN12 catalytic domain 1-301
    
  • 5glj - hPTPN13 PDZ1 domain 1086-1178
    
  • 1wch - hPTPN13 2163-2477
    
  • 2bzl – hPTPN14 catalytic domain 886-1187
    
  • 2oc3 – hPTPN18 catalytic domain 6-299
    
  • 8gvl – hPTPN21 FERM domain 18-318
    
  • 8gvv – hPTPN21 PTP domain 876-1174 (mutant)
    
  • 8gxe – hPTPN21 FERM+PTP domains
    
  • 2p6x, 2qcj, 3h2x – hPTPN22 catalytic domain 1-302
    
  • 5cru, 5mjz, 3rau – hRPTP23 domain Bro residues 1-361
    
  • 5lm2 – hRPTP23 residues 362-713
    
  • 1rxd, 1xm2 – hPTP PRL-1
    
  • 1r6h, 1v3a, 2mbc – hPTP PRL-3 – NMR
    
  • 1bvh - bPTP – bovine – NMR
    
  • 1c0e – bPTP (mutant) – bovine
    
  • 1zck, 1x24 – rPTP 4A1 – rat
    
  • 3i36 – rPTP- catalytic domain
    
  • 1gm1 - mPTP-BL PDZ2 domain – mouse – NMR
    
  • 1ozi - mPTP-BL PDZ2 domain (mutant) – NMR
    
  • 3rgo – mPTP-1
    
  • 3rgq – mPTP-1 + Pi(5)P
    
  • 2yz1 – mPTP SHPS-1 catalytic domain
    
  • 6x39 – mPTP F FN#5 domain
    
  • 6gbd – mPTP-13 SH3 domain - NMR
    
  • 2pi7 – cPTP CRYP-2 catalytic domain – chicken
    
  • 7mod, 7moi, 7moj, 7mok, 7mol, 7mom – AtPTP DSP1 49-215 – Arabidopsis thaliana
    
  • 6krw, 6krx – AtPTP1 1-340
    
  • 1d1p, 2j16 – yPTP – yeast
    
  • 2j17 - yPTP (mutant)
    
  • 5xw4 – yPTPN CDC14
    
  • 6e3b – yPTPN SIW14 catalytic domain
    
  • 1g4w – StPTP – Salmonella typhimurium
    
  • 2i6i, 3ro1 – SsPTP – Sulfolobus solfataricus
    
  • 2z72, 1v73, 2zbm – PTP residues 22-361 – Shewanella
    
  • 3js5, 3jvi – EhPTP – Entamoeba histolytica
    
  • 2wjd, 2wje, 2wjf – PTP – Streptococcus pneumonia
    
  • 3qy6, 3qy7, 3qy8 – BsPTP – Bacillus subtilis
    
  • 4d74 – PTP AMSI 1-144 (mutant) – Erwinia amylovora
    
  • 8dhi, 8dhj – PTP 1-246 (mutant) – Clostridioides difficile
    

• Non-receptor type PTP complex with peptide

• • 1ptt, 1ptu, 1g1f, 1g1g, 1g1h, 1een, 1eeo, 8exj, 8exk, 8exm, 8exn, 8eya, 8eyb, 8eyc, 8f88 - hPTP-1b catalytic domain (mutant) + peptide
    
  • 3i7z - hPTP-b catalytic domain + peptide
    
  • 7qcy - hPTP-1e PDZ2 domain + peptide – NMR
    

3zmp, 3zmq, 4zrt – hPTPN1 catalytic domain + peptide

• • 4qum, 4rh5, 4rh9, 4rhg, 4s0g – hPTPN3 catalytic domain (mutant) 628-909 + peptide
    
  • 6hks, 6t36, 8cqy, 8oep – hPTPN3 PDZ domain 489-597 + peptide
    
  • 3nfk, 3nfl, 5eyz, 5ez0 - hPTPN4 PDZ domain + peptide
    
  • 7vze - hPTPN4 PDZ domain + papillomavirus peptide
    
  • 3d42, 3d44 – hPTPN7 catalytic domain (mutant) + peptide
    
  • 4icz, 6kzq, 6l03 – hPTPN9 catalytic domain + peptide
    
  • 5o2p – hPTPN12 SH3 domain/peptide
    
  • 3lny, 7xty - hPTPN13 PDZ2 domain 1362-1456 + peptide
    
  • 4gfu, 4gfv - hPTPN18 residues 6-300 + peptide
    
  • 4nnd - hPTPN18 residues 6-300 (mutant) + ERBB-2
    
  • 3brh, 3olr - hPTPN22 catalytic domain + peptide
    
  • 3omh - hPTPN22 catalytic domain (mutant) + peptide
    
  • 5crv, 5mk3, 5mk2, 5mk1, 5mk0, 5mjy – hRPTP23 domain Bro + peptide
    
  • 5lm1 – hRPTP23 residues 362-713 + UBAP-1 peptide
    
  • 3rz2 - rPTP 4A1 + peptide
    
  • 1aya, 1ayb, 1ayc, 1ayd – mPTP Syp N terminal SH2 domain + peptide
    
  • 1vj6 – mPTP-BL PDZ2 domain + APC C terminal – NMR
    
  • 6gbe – mPTPN13 PDZ3 domain + PRK2 peptide – NMR
    
  • 5xw5 – yPTPN CDC14 + SWI6 peptide
    
  • 6g86 – yPTPN CDC14 + SIC1 peptide
    
  • 6g85, 6g84 – yPTPN CDC14 + CBK1 peptide
    
  • 2dxp, 2i6o – SsPTP (mutant) + peptide
    

• Non-receptor type PTP complex with small molecule

• • 1ptv, 1pty - hPTP-1b catalytic domain (mutant) + phosphotyrosine
    
  • 1aax - hPTP-1b catalytic domain (mutant) + bis-phosphophenyl methane
    
  • 1ecv, 1c83, 1c84, 1c85, 1c86, 1c87, 1c88, 1g7f, 1g7g, 1jf7, 1l8g, 1kak, 1kav, 1lqf, 1nl9, 1nny, 1no6, 1nz7, 1ony, 1onz, 1ph0, 1pxh, 1pyn, 1q1m, 1q6j, 1q6m, 1q6n, 1q6p, 1q6s, 1q6t, 1qxk, 1t48, 1t49, 1t4j, 1xbo, 1wax, 2bgd, 2bge, 2azr, 2b07, 2f6t, 2f6v, 2f6w, 2f6y, 2f6z, 2f70, 2f71, 2fjn, 2cm7, 2cm8, 2cma, 2cmb, 2cmc, 2h4g, 2h4k, 2hb1, 2cne, 2cnf, 2cng 2cnh, 2cni, 2nt7, 2nta, 2veu, 2vev, 2vew, 2vex, 2vey, 2qbp, 2qbq, 2qbr, 2qbs, 3cwe, 3d9c, 2zmm, 2zn7, 3eax, 3eb1, 3sme, 4i8n, 4y14, 5t19, 5k9w, 6w30, 7gs7, 7gsa, 7gsb, 7gsl, 7gsm, 7gso, 7gsr, 7gst, 7gsv, 7gsw, 7gsy, 7gt0, 7gt1, 7gt3, 7gt4, 7gt5, 7gt6, 7gt7, 7gt9, 7gta, 7gtd, 7gte, 7gtg, 7gth, 7gti, 7gtk, 7gtl, 7gtm, 7gtn, 7gto, 7gtt, 7gtu, 7klx, 7mm1, 8g6a, 8g65, 8g67, 8g68, 8g69, 8skl - hPTP-1b catalytic domain 1-298 + inhibitor
    
  • 1nwl, 1nwe, 2fjm, 5ka3, 5ka7, 5ka9, 5kab, 5kac, 5kad, 5qde, 5qdf, 5qdg, 5qdh, 5qdi, 5qdj, 5qdk, 5qdl, 5qdm, 5qdn, 5qdo, 5qdp, 5qdq, 5qdr, 5qds, 5qdt, 5qdu, 5qdv, 5qdw, 5qdx, 5qdy, 5qdz, 5qe0, 5qe1, 5qe2, 5qe3, 5qe4, 5qe5, 5qe6, 5qe7, 5qe8, 5qe9, 5qea, 5qeb, 5qec, 5qed, 5qee, 5qef, 5qeg, 5qeh, 5qei, 5qej, 5qek, 5qel, 5qem, 5qen, 5qeo, 5qep, 5qeq, 5qer, 5qes, 5qet, 5qeu, 5qev, 5qew, 5qex, 5qey, 5qez, 5qf0, 5qf1, 5qf2, 5qf3, 5qf4, 5qf5, 5qf6, 5qf7, 5qf8, 5qf9, 5qfa, 5qfb, 5qfc, 5qfd, 5qfe, 5qff, 5qfg, 5qfh, 5qfi, 5qfj, 5qfk, 5qfl, 5qfm, 5qfn, 5qfo, 5qfp, 5qfq, 5qfr, 5qfs, 5qft, 5qfu, 5qfv, 5qfw, 5qfx, 5qfy, 5qfz, 5qg0, 5qg1, 5qg2, 5qg3, 5qg4, 5qg5, 5qg6, 5qg7, 5qg8, 5qg9, 5qga, 5qgb, 5qgc, 5qgd, 5qge, 5qgf, 7fqm, 7fqn, 7fqo, 7fqp, 7fqq, 7fqr, 7fqs, 7fqu, 7fqv, 7fqw, 7fqx, 7fqy, 7fqz, 7frg, 7frh, 7fri, 7frj, 7frk, 7frl, 7frm, 7frn, 7fro, 7frp, 7frq, 7frr, 7gs9, 7gsd, 7gse, 7gsf, 7gsg, 7gsh, 7gsi, 7gsj, 7gsk, 7gsn, 7gsq, 7gsu, 7gsx, 7gsz, 7gt8, 7gtb, 7gtc, 7gtf, 7gtj, 7gtp, 7gtq, 7gtr, 7gts, 7gtv, 7mn7, 7mna, 7mnb, 7mnd, 7mne, 7mnf, 7mow - hPTP-1b catalytic domain (mutant) + inhibitor
    
  • 4bjo – hPTP1 catalytic domain + NO3
    
  • 6xed, 6xeg – hPTPN1b + WO4
    
  • 6xea – hPTPN1b + VO4
    
  • 6pm8, 6xef, 7l0h – hPTPN1b (mutant) + VO4
    
  • 7uad – hPTPN2 1-314 + inhibitor
    
  • 4ri4, 4ri5 – hPTPN3 catalytic domain (mutant) + VO4
    
  • 2cjz - hPTPN5 catalytic domain 258-563 (mutant) + phosphotyrosine
    
  • 5ow1, 5ovx, 5ovr – hPTP5 catalytic domain + inhibitor
    
  • 4ge2, 4ge5, 4ge6 – hPTP9 catalytic domain + inhibitor
    
  • 2m10 - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR
    
  • 2qct, 4j51 – hPTPN22 catalytic domain + inhibitor
    
  • 5bx1 – hPTP PRL-1 + inhibitor
    
  • 1dg9 – bPTP + HEPES
    
  • 1zcl - rPTP 4A1 (mutant) + sulfate
    
  • 7moe, 7mof, 7mog, 7moh – AtPTP DSP1 + inhibitor
    
  • 1d2a – yPTP + adenine
    
  • 1d1q – yPTP (mutant) + PNPP
    
  • 2i6p - SsPTP (mutant) + PNPP
    
  • 2i6j – SsPTP + phosphate
    
  • 2i6m – SsPTP + WO4
    
  • 3ido – EhPTP + HEPES
    
  • 7mpd – SsoPTP + inhibitor – Ssccharolobus solfataricus
    
  • 7mpc – SsoPTP + VO4
    
  • 7ezn – PTP + VO4 – Cryptococcus neoformans
    

• Non-receptor type PTP complex with protein

• • 2b4s - hPTP-b catalytic domain + insulin receptor
    
  • 2gph - hPTPN7 catalytic domain (mutant) + MAPK2
    
  • 6iwd – hPTPN14 886-1187 + HPV18 CR3 domain
    
  • 5k25, 5k24, 5k23 – hPTP PRL-2 + CNNM3
    
  • 5k22 – hPTP PRL-2 (mutant) + CNNM3
    
  • 5tsr – hPTP PRL-3 (mutant) + CNNM3
    
  • 6nmv, 6nmu, 6nmt, 6nms, 6nmr, 6bit - hPTP SHPS-1 + antibody
    
  • 5lxq – mPTP PRL-1 + CNNM2
    
  • 6wus – mPTP PRL-1 (mutant) + CNNM2
    
  • 5mmz – mPTP 4A1 + CNNM2
    
  • 4pbv, 4pbw – cPTP CRYP-alpha1 29-316 + TrkC
    
  • 4zj7 – yPTPN CDC14 C terminal + importin
    
  • 1g4u – StPTP + RAS-related C3 botulinum toxin substrate
    
  • 1jyo – StPTP + secretion chaperone SICP
    

• Non-receptor type PTP SHP-1 or tyrosine-protein phosphatase non-receptor type 6

• • 3ps5 – hPTP SHP-1 (mutant)
    
  • 1gwz, 2b3o, 4hjp – hPTP SHP-1 catalytic domain 242-528
    
  • 4gry, 4grz, 4hjq – hPTP SHP-1 catalytic domain (mutant)
    
  • 1x6c - hPTP SHP-1 C-terminal SH2 domain 105-220 – NMR
    
  • 2dju, 2edy – hPTP SHP-1 FN #3 domain 309-401 NMR
    
  • 2dn7 – hPTP SHP-1 FN3 #6 domain 811-904 - NMR
    
  • 1fpr, 4gs0 - hPTP SHP-1 catalytic domain + peptide
    
  • 2rmx, 2yu7 – hPTP SHP-1 C-terminal SH2 domain + peptide – NMR
    
  • 6sm5 - hPTP SHP-1 C-terminal SH2 domain + monobody
    

• Non-receptor type PTP SHP-2 or tyrosine-protein phosphatase non-receptor type 11

• • 4dgp – hPTP SHP-2 SH2+catalytic domains 1-532
    
  • 2shp, 4dgx, 4gwf, 4h1o, 4h34, 4nwf, 4nwg, 4ohd, 4ohe, 4ohh, 4ohi, 4ohl, 5bk8, 6ihz, 6crf, 6cmp – hPTP SHP-2 SH2+catalytic domains (mutant)
    
  • 6cmq - hPTP SHP-2 106-529
    
  • 3b7o, 3zm0, 3zm1, 3zm2, 3zm3 – hPTP SHP-2 catalytic domain 248-527
    
  • 5j8r, 5i6v, 5ibm, 5ibs, 7emn – hPTP SHP-2 catalytic domain (mutant)
    
  • 3tl0, 3tkz, 4qsy, 5df6, 5x7b, 5x94 – hPTPN11 SH2 domain 1-220 + peptide
    
  • 6roy - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITIM peptide
    
  • 6roz - hPTP SHP-2 N- terminal SH2 domain + ITSM peptide
    
  • 6r5g - hPTP SHP-2 SH2 domain 105-220 + ITSM peptide – NMR
    
  • 7ppl, 7ppm, 7ppn - hPTP SHP-2 catalytic domain (mutant) + peptide
    
  • 3mow - hPTP SHP-2 catalytic domain + inhibitor
    
  • 3o5x, 4pvg, 4rdd, 5ehp, 5ehr, 5xzr, 6md7, 6md9, 6mda, 6mdb, 6mdc, 6mdd, 6wu8, 7jvm, 7jvn, 7r75, 7r7d, 7r7i, 7r7l, 7rct, 7vxg, 8b5y, 8cbh, 8t6d, 8u7w, 8u7x - hPTP SHP-2 SH2+catalytic domains + inhibitor
    
  • 6cmr, 6cms, 6crg - hPTP SHP-2 SH2+catalytic domains (mutant) + inhibitor
    
  • 8t7q - hPTP SHP-2 SH2+catalytic domains + drug
    
  • 4je4, 4jeg – hPTP SHP-2 N-terminal SH2 domain + monobody
    
  • 7tvj – hPTP SHP-2 catalytic domain 224-525 + monobody
    

• Yersinia PTP Yop

• • 1yts, 4yaa, 4z6b, 4zi4, 4zn5, 6xft - YePTP catalytic domain (mutant) – Yersinia enterocolitica
    
  • 7l0i – YePTP (mutant)
    
  • 1xxp, 1xxv - YePTP catalytic domain (mutant) + peptide
    
  • 2i42, 7l0m – YePTP (mutant) + VO4
    
  • 1ypt, 1ytw – YePTP catalytic domain + WO4
    
  • 1ytn - YePTP catalytic domain + NO3
    
  • 1lyv - YePTP catalytic domain (mutant) + phosphate
    
  • 1pa9, 3bm8 - YePTP catalytic domain (mutant) + inhibitor
    
  • 3u96 - YePTP catalytic domain (mutant) + PNCS
    
  • 1huf – YpPTP - Yersinia pestis
    
  • 1qz0 - YpPTP catalytic domain + peptide
    
  • 2y2f - YpPTP catalytic domain + inhibitor
    
  • 1k46 - YpPTP N terminal domain
    
  • 1m0v - YpPTP N terminal domain + peptide – NMR
    
  • 4gf3 – YpPTP + Yop targeting protein
    

• Receptor-type PTP

• • 1yfo, 2i1y – mRPTP-α catalytic domain
    
  • 1p15 - mRPTP-α D2 domain
    
  • 3pxh - mRPTP Ig domains
    
  • 1jln, 2a8b - mRPTP-R catalytic domain
    
  • 3sr9 - mRPTP-σ residues 1326 – 1901
    
  • 2nv5 – rRPRP
    
  • 2yd4 - cRPTP-σ Ig1-2 domain – chicken
    
  • 2yd1, 2yd2, 3pxj – DmRPTP Ig1-2 domain – Drosophila melanogaster
    
  • 3s3e – DmRPTP-10D catalytic domain
    
  • 6x38 – DmRPTP FN5 domain
    

• Human receptor-type PTP

• • 6uzt - hRPTP-α catalytic domain
    
  • 2ahs – hRPTP-β
    
  • 2i3r, 2i5x - hRPTP-β catalytic domain
    
  • 2hc1, 2hc2 - hRPTP-β catalytic domain (mutant)
    
  • 2h4v, 2pbn, 3qcb – hRPTP-γ domain 1
    
  • 3qcn - hRPTP-γ domain 1 (mutant)
    
  • 2nlk - hRPTP-γ catalytic domain
    
  • 3jxh - hRPTP-γ CA-like domain
    
  • 5fmv - hRPTP-γ domain D1-D4
    
  • 5fn6 - hRPTP-γ domain D1-D3
    
  • 5fn7 - hRPTP-γ domain D1-D2
    
  • 5fn8 - rRPTP-γ domain D3-D4
    
  • 4yfe - hRPTP-δ FN1-FN2 domain 321-511
    
  • 4yfg - hRPTP-δ Ig1-FN1 domain 21-501
    
  • 2dlh, 1x5z - hRPTP-δ FN3 domain 405-514 – NMR
    
  • 2yd6, 2yd7 - hRPTP-δ Ig1-2 domain 21-220
    
  • 6x3a - hRPTP-δ FN4-FN6 domain 607-916
    
  • 2jjd - hRPTP-ε residues 107-697
    
  • 6d4d - hRPTP-ε domain D1 residues 22-313
    
  • 6d4f, 6d3f - hRPTP-ε domain D2 residues 425-700
    
  • 8a1f - hRPTP-kappa N-terminal residues 28-385
    
  • 2c7s - hRPTP-kappa residues 865-1154
    
  • 1rpm - hRPTP-μ catalytic domain
    
  • 2c9a - hRPTP-μ MAM-IG module
    
  • 2v5y - hRPTP-μ extracellular region
    
  • 8a16, 8a17 - hRPTP- FN#3-4 domain 478-723
    
  • 2g59, 2gjt - hRPTP- catalytic domain
    
  • 7u08 - hRPTP-eta residues 37-374
    
  • 7u01 - hRPTP-eta residues 206-364
    
  • 2cfv – hRPTP-eta residues 1019-1311
    
  • 2nz6 - hRPTP-eta residues 1019-1311 (mutant)
    
  • 2dle - hRPTP-eta FN3 domain – NMR
    
  • 2qep – hRPTP-ν2 D1 domain
    
  • 4hti, 4htj – hRPTP-ν2 membrane proximal ectodomain
    
  • 2ooq – hRPTP-ρ
    
  • 2fh7, 4bpc - hRPTP-σ catalytic domain (mutant)
    
  • 2yd9 - hRPTP-σ Ig1-3 domain (mutant)
    
  • 2yd3, 2yd5 - hRPTP-σ Ig1-2 domain
    
  • 4pbx - hRPTP-σ residues 30-588
    
  • 3jxf - hRPTP-ζ CA-like domain
    
  • 5awx - hRPTP-ζ D1 domain
    
  • 2qt7, 3n01, 3n4w, 3ng8, 3np5 – hRPTP IA-2
    
  • 6tpv - hRPTP-F 1st-2nd FN3 domain 319-512
    
  • 6tpu, 6tpt - hRPTP-F 3rd-4th FN3 domain 513-705
    
  • 4n5u - hRPTP-F 4th FN3 domain 601-705
    
  • 2edx - hRPTP-F 4th FN3 domain – NMR
    
  • 6tpw - hRPTP-F 1st-4th FN3 domain
    
  • 6j6u - rRPTP-ζ D1-D2 domain
    
  • 3jxg, 3jxh - mRPTP-γ CA-like domain
    
  • 7xc0 - hRPTP-H 797-1086
    

• Receptor-type PTP complexes

• • 2h02, 2h04, 2i3u, 2i4e, 2i4g, 2i4h - hRPTP-β catalytic domain + inhibitor
    
  • 2h03 - hRPTP-β catalytic domain (mutant) + inhibitor
    
  • 2hy3, 3qcc, 3qcd - hRPTP-γ domain 1 + VO4
    
  • 3qce, 3qcf, 3qcg, 3qch, 3qci, 3qcj, 3qck - hRPTP-γ domain 1 + inhibitor
    
  • 3qcl, 3qcm - hRPTP-γ domain 1 (mutant) + inhibitor
    
  • 5e5r - hRPTP-γ domain CA + contactin 3
    
  • 4rca, 4y61 - hRPTP-δ Ig1-Ig2 domain 21-318 + SLITRK1
    
  • 5xnp - hRPTP-δ Ig1-Ig2 domain (mutant) + SALM5
    
  • 6kip - hRPTP-δ residues 1617-1912 + liprin
    
  • 5y32, 4yfd, 4yh7, 5wy8 - hRPTP-δ Ig1-Ig2 domain + IL1RAPL1
    
  • 5xnp - hRPTP-d Ig1-Ig2 domain (mutant) + SALM5
    
  • 6kip - hRPTP-d residues 1617-1912 + liprin
    
  • 2yd8 - hRPTP-σ Ig1-2 domain + sucrose octasulfate
    
  • 3s97 - hRPTP-zeta CA-like domain 34-302 + congtactin Ig domains
    
  • 8fn8, 8fn9 – hPTP zeta FN domain 310-411 + tenascin fg domain
    
  • 5h08 – hPTP zeta D1 domain 1698-1993 + inhibitor
    
  • 6kr4 - hRPTP-F residues 1332-1907 + liprin
    
  • 1ygr – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide
    
  • 5e5u - mRPTP-γ domain CA + contactin 6
    
  • 3kld - mRPTP-γ CA-like domain + contactin 4
    
  • 5xwu - mRPTP- Ig1-Ig3 domain + LRR-IG
    
  • 5xwt - mRPTP- Ig1-FN1 domain + LRR-IG
    
  • 3s3f - DmRPTP-10D catalytic domain + VO4
    
  • 3s3h - DmRPTP-10D catalytic domain + peptide
    
  • 3s3k - DmRPTP-10D catalytic domain + inhibitor
    

• Dual-specificity PTP DUSP see Map kinase phosphatase

• Class II – Low molecular weight PTP (LMW-PTP)

• • 1xww, 4z99, 5jnr, 5jns, 5jnt – hLMW-PTP
    
  • 6y2v, 6y2w – hLMW-PTP (mutant)
    
  • 1phr – bLMW-PTP
    
  • 5jnv – bLMW-PTP (mutant)
    
  • 5jnu – mLMW-PTP
    
  • 7cuy – DmLMW-PTP
    
  • 1p8a – LMW-PTP (mutant) – Tritrichomonas foetus – NMR
    
  • 2cwd – LMW-PTP – Thermus thermophilus
    
  • 5got – LMW-PTP – Streptococcus pyogenes
    
  • 1u2p, 2luo – MtLMW-PTP – Mycobacterium tuberculosis
    
  • 2fek, 2wja – LMW-PTP Wzb – Escherichia coli
    
  • 4eti, 4etm, 4kk3 – BsLMW-PTP
    
  • 4etn, 4kk4 – BsLMW-PTP (mutant)
    
  • 7dhd – VvLMW-PTP Wzb – Vibrio vulnificus
    
  • 4egs – LMW-PTP N-terminal 1-146 – Thermoanaerobacter tengcongensis
    
  • 2gi4 – LMW-PTP – Campylobacter jejuni
    

• LMW-PTP complex

• • 3n8i, 5kqg, 5kql, 5kqm, 5kqp, 7kh8, 7uw6 – hLMW-PTP + inhibitor
    
  • 4z9a – hLMW-PTP + phenylmethanesulfonic acid
    
  • 4z9b – hLMW-PTP + benzylphosphonic acid
    
  • 1z12 - bLMW-PTP + VO4
    
  • 1z13 - bPTP + MoO4
    
  • 5jnw – bLMW-PTP + inhibitor
    
  • 3rof – LMW-PTP-A + peptide – Staphylococcus aureus
    
  • 1u2q – MtLMW-PTP + glycerol
    
  • 2oz5 – MtLMW-PTP + inhibitor
    
  • 7dhe, 7dhf – VvLMW-PTP Wzb + inhibitor
    

• For LMW-PTP from Synechocystis see Arsenate reductase

• Class III – CDC25 or M-phase inducer phosphatase 2

• • 1c25 – hCDC25A catalytic domain (mutant)
    
  • 1qb0, 1cwr, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq - hCDC25B catalytic domain
    
  • 2a2k, 2ifd, 2ifv - hCDC25B catalytic domain (mutant)
    
  • 4wh7 - hCDC25B catalytic domain (mutant) + ligand
    
  • 4wh9 - hCDC25B catalytic domain (mutant) + inhibitor
    
  • 1cwr, 1cws - hCDC25B catalytic domain + WO4
    
  • 1cwt - hCDC25B catalytic domain + Methyl-Hg
    
  • 3op3 – hCDC25C residues 270-462

• Class IV

• • 4tvv – PTP – Legionella pneumophila
    

• T-cell tyrosine phosphatase

• • 1l8k – hTC-PTP

• Other tyrosine phosphatases

• • 4az1 – PTP – Trypanosoma cruzi
    
  • 4r0s – PaPTP – Pseudomonas aeruginosa
    
  • 4r0t – PaPTP (mutant) + tyrosine
    
  • 5ncr – PTP (mutant) – ORF virus
    

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