Structural highlights
Function
[ACRR_ECOLI] Potential regulator protein for the acrAB genes.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The Escherichia coli AcrR multidrug-binding protein represses transcription of acrAB and is induced by many structurally unrelated cytotoxic compounds. The crystal structure of AcrR in space group P222(1) has been reported previously. This P222(1) structure has provided direct information about the multidrug-binding site and important residues for drug recognition. Here, a crystal structure of this regulator in space group P3(1) is presented. Comparison of the two AcrR structures reveals possible mechanisms of ligand binding and AcrR regulation.
Conformational change of the AcrR regulator reveals a possible mechanism of induction.,Gu R, Li M, Su CC, Long F, Routh MD, Yang F, McDermott G, Yu EW Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt, 7):584-8. Epub 2008 Jun 11. PMID:18607081[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gu R, Li M, Su CC, Long F, Routh MD, Yang F, McDermott G, Yu EW. Conformational change of the AcrR regulator reveals a possible mechanism of induction. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt, 7):584-8. Epub 2008 Jun 11. PMID:18607081 doi:10.1107/S1744309108016035
