Structural highlights
Function
O28769_ARCFU
Publication Abstract from PubMed
We describe an algorithm for phasing protein crystal X-ray diffraction data that identifies, retrieves, refines and exploits general tertiary structural information from small fragments available in the Protein Data Bank. The algorithm successfully phased, through unspecific molecular replacement combined with density modification, all-helical, mixed alpha-beta, and all-beta protein structures. The method is available as a software implementation: Borges.
Exploiting tertiary structure through local folds for crystallographic phasing.,Sammito M, Millan C, Rodriguez DD, de Ilarduya IM, Meindl K, De Marino I, Petrillo G, Buey RM, de Pereda JM, Zeth K, Sheldrick GM, Uson I Nat Methods. 2013 Sep 15. doi: 10.1038/nmeth.2644. PMID:24037245[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Sammito M, Millan C, Rodriguez DD, de Ilarduya IM, Meindl K, De Marino I, Petrillo G, Buey RM, de Pereda JM, Zeth K, Sheldrick GM, Uson I. Exploiting tertiary structure through local folds for crystallographic phasing. Nat Methods. 2013 Sep 15. doi: 10.1038/nmeth.2644. PMID:24037245 doi:10.1038/nmeth.2644
