Structural highlights
Publication Abstract from PubMed
PreQ1 riboswitches regulate genes by binding the pyrrolopyrimidine intermediate preQ1 during the biosynthesis of the essential tRNA base queuosine. We report what is to our knowledge the first preQ1-II riboswitch structure at 2.3-A resolution, which uses a previously uncharacterized fold to achieve effector recognition at the confluence of a three-way helical junction flanking a pseudoknotted ribosome-binding site. The results account for translational control mediated by the preQ1-II riboswitch class and expand the known repertoire of ligand-binding modes used by regulatory RNAs.
Structure of a class II preQ riboswitch reveals ligand recognition by a new fold.,Liberman JA, Salim M, Krucinska J, Wedekind JE Nat Chem Biol. 2013 Apr 14. doi: 10.1038/nchembio.1231. PMID:23584677[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Liberman JA, Salim M, Krucinska J, Wedekind JE. Structure of a class II preQ riboswitch reveals ligand recognition by a new fold. Nat Chem Biol. 2013 Apr 14. doi: 10.1038/nchembio.1231. PMID:23584677 doi:10.1038/nchembio.1231
