4ruh

Structural highlights

Function

CNDP2_HUMAN Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.^{[1] [2]}

References

1. ↑ Zhang P, Chan DW, Zhu Y, Li JJ, Ng IO, Wan D, Gu J. Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma. Clin Cancer Res. 2006 Nov 15;12(22):6617-25. PMID:17121880 doi:http://dx.doi.org/10.1158/1078-0432.CCR-06-1307
2. ↑ Kaur H, Kumar C, Junot C, Toledano MB, Bachhawat AK. Dug1p Is a Cys-Gly peptidase of the gamma-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases. J Biol Chem. 2009 May 22;284(21):14493-502. doi: 10.1074/jbc.M808952200. Epub, 2009 Apr 3. PMID:19346245 doi:10.1074/jbc.M808952200