Structural highlights
Function
PG130_VACCW Component of the virion core. Participates in virion assembly.[1] [2]
Publication Abstract from PubMed
Poxviruses such as variola virus (smallpox) and monkeypox cause diseases in humans. Other poxviruses, including vaccinia and modified vaccinia Ankara, are used as vaccine vectors. Given their importance, a greater structural understanding of poxvirus virions is needed. We now performed cryo-electron tomography of purified intact vaccinia virions to study the structure of the palisade, a protein lattice that defines the viral core boundary. We identified the main viral proteins that form the palisade and their interaction surfaces and provided new insights into the organization of the viral core.
Palisade structure in intact vaccinia virions.,Hernandez-Gonzalez M, Calcraft T, Nans A, Rosenthal PB, Way M mBio. 2024 Jan 3:e0313423. doi: 10.1128/mbio.03134-23. PMID:38171004[3]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Risco C, Rodríguez JR, Demkowicz W, Heljasvaara R, Carrascosa JL, Esteban M, Rodríguez D. The vaccinia virus 39-kDa protein forms a stable complex with the p4a/4a major core protein early in morphogenesis. Virology. 1999 Dec 20;265(2):375-86. PMID:10600608 doi:10.1006/viro.1999.0046
- ↑ Risco C, Rodríguez JR, López-Iglesias C, Carrascosa JL, Esteban M, Rodríguez D. Endoplasmic reticulum-Golgi intermediate compartment membranes and vimentin filaments participate in vaccinia virus assembly. J Virol. 2002 Feb;76(4):1839-55. PMID:11799179 doi:10.1128/jvi.76.4.1839-1855.2002
- ↑ Hernandez-Gonzalez M, Calcraft T, Nans A, Rosenthal PB, Way M. Palisade structure in intact vaccinia virions. mBio. 2024 Jan 3:e0313423. PMID:38171004 doi:10.1128/mbio.03134-23
