Structural highlights
Publication Abstract from PubMed
We describe the packing features of the oligonucleotide duplex d(AAATTT)2, as determined by X-ray diffraction. There is little information on sequences that only contain A and T bases. The present structure confirms that these sequences tend to pack as a helical arrangement of stacked oligonucleotides in a B conformation with Watson-Crick hydrogen bonding. Our results demonstrate that the virtual TA base step between stacked duplexes has a negative twist that improves base stacking. This observation is consistent with the low stability of TA base steps in B-form DNA.
Packing features of the all-AT oligonucleotide d(AAATTT).,Valls N, Santaolalla A, Campos JL, Subirana JA J Biomol Struct Dyn. 2007 Jun;24(6):547-52. PMID:17508776[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Valls N, Santaolalla A, Campos JL, Subirana JA. Packing features of the all-AT oligonucleotide d(AAATTT). J Biomol Struct Dyn. 2007 Jun;24(6):547-52. PMID:17508776
