Structural highlights
Function
SRP19_METJA Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (By similarity).
Publication Abstract from PubMed
The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-A structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180 degrees flip of the NG domain-structural changes that ensure a hierarchical succession of events during protein targeting.
Structural basis of signal-sequence recognition by the signal recognition particle.,Hainzl T, Huang S, Merilainen G, Brannstrom K, Sauer-Eriksson AE Nat Struct Mol Biol. 2011 Mar;18(3):389-91. Epub 2011 Feb 20. PMID:21336278[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Hainzl T, Huang S, Merilainen G, Brannstrom K, Sauer-Eriksson AE. Structural basis of signal-sequence recognition by the signal recognition particle. Nat Struct Mol Biol. 2011 Mar;18(3):389-91. Epub 2011 Feb 20. PMID:21336278 doi:10.1038/nsmb.1994
