Structural highlights
Publication Abstract from PubMed
Multinuclear silver clusters encapsulated by DNA exhibit size-tunable emission spectra and rich photophysics, but their atomic organization is poorly understood. Herein, we describe the structure of one such hybrid chromophore, a green-emitting Ag8 cluster arranged in a Big Dipper shape bound to the oligonucleotide A2C4. Three 3' cytosine metallo-base pairs stabilize a parallel A-form-like duplex with a 5' adenine-rich pocket, which binds a metallic, trapezoidal-shaped Ag5 moiety via Ag-N bonds to endo- and exo-cyclic nitrogens of cytosine and adenine. The unique DNA configuration, constrained coordination environment, and templated Ag8 cluster arrangement highlight the reciprocity between the silvers and DNA in adopting this structure. These first atomic details of a DNA-encapsulated Ag cluster fluorophore illuminate many aspects of biological assembly, nanoscience, and metal cluster photophysics.
Atomic structure of a fluorescent Ag8 cluster templated by a multi-stranded DNA scaffold.,Huard DJE, Demissie A, Kim D, Lewis D, Dickson RM, Petty JT, Lieberman RL J Am Chem Soc. 2018 Dec 18. doi: 10.1021/jacs.8b12203. PMID:30562465[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Huard DJE, Demissie A, Kim D, Lewis D, Dickson RM, Petty JT, Lieberman RL. Atomic structure of a fluorescent Ag8 cluster templated by a multi-stranded DNA scaffold. J Am Chem Soc. 2018 Dec 18. doi: 10.1021/jacs.8b12203. PMID:30562465 doi:http://dx.doi.org/10.1021/jacs.8b12203
