3ssb

Structural highlights

Function

[THER_BACTH] Extracellular zinc metalloprotease. [IMPI_GALME] Inhibits thermolysin, bacillolysin and pseudolysin, B.polymyxa metalloprotease and human MMP1 and MMP3. No activity on trypsin or cysteine protease papain.^{[1] [2]}

See Also

• Thermolysin 3D structures

References

1. ↑ Clermont A, Wedde M, Seitz V, Podsiadlowski L, Lenze D, Hummel M, Vilcinskas A. Cloning and expression of an inhibitor of microbial metalloproteinases from insects contributing to innate immunity. Biochem J. 2004 Aug 15;382(Pt 1):315-22. PMID:15115439 doi:http://dx.doi.org/10.1042/BJ20031923
2. ↑ Wedde M, Weise C, Kopacek P, Franke P, Vilcinskas A. Purification and characterization of an inducible metalloprotease inhibitor from the hemolymph of greater wax moth larvae, Galleria mellonella. Eur J Biochem. 1998 Aug 1;255(3):535-43. PMID:9738891