1r2q
From Proteopedia
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, resolution 1.05Å | |||||||
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Ligands: | , , | ||||||
Gene: | RAB5A OR RAB5 (Homo sapiens) | ||||||
Related: | 1N6H, 1N6I, 1N6K, 1N6L, 1N6N
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Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
Coordinates: | save as pdb, mmCIF, xml |
Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution
Overview
Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP-analog molecule. It provides the highest resolution three-dimensional model so far obtained for proteins from the Ras-like GTPase family. This study allows extension of structural examination of the GTPase machinery as well as of high-resolution protein structures in general. For example, a buried water-molecule network was observed underneath the switch regions, which is consistent with the functional roles of these regions in the molecular-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-like GTPases.
About this Structure
1R2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution., Terzyan S, Zhu G, Li G, Zhang XC, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):54-60. Epub 2003, Dec 18. PMID:14684892
Page seeded by OCA on Sun Mar 30 23:22:27 2008
Categories: Homo sapiens | Single protein | Li, G. | Terzyan, S. | Zhang, X C. | Zhu, G. | Atomic resolution | Gnp | Gtpase | Rab