Structural highlights
Function
[PUF7_CAEEL] RNA-binding protein that binds to the consensus sequence 5'-CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis.[1] [2] [3]
References
- ↑ Lublin AL, Evans TC. The RNA-binding proteins PUF-5, PUF-6, and PUF-7 reveal multiple systems for maternal mRNA regulation during C. elegans oogenesis. Dev Biol. 2007 Mar 15;303(2):635-49. Epub 2006 Dec 8. PMID:17234175 doi:http://dx.doi.org/10.1016/j.ydbio.2006.12.004
- ↑ Qiu C, Kershner A, Wang Y, Holley CP, Wilinski D, Keles S, Kimble J, Wickens M, Hall TM. Divergence of Pumilio/fem-3 mRNA binding factor (PUF) protein specificity through variations in an RNA-binding pocket. J Biol Chem. 2012 Feb 24;287(9):6949-57. Epub 2011 Dec 28. PMID:22205700 doi:http://dx.doi.org/10.1074/jbc.M111.326264
- ↑ Hubstenberger A, Cameron C, Shtofman R, Gutman S, Evans TC. A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans. Dev Biol. 2012 Jun 15;366(2):218-31. doi: 10.1016/j.ydbio.2012.03.019. Epub 2012 , Apr 19. PMID:22542599 doi:http://dx.doi.org/10.1016/j.ydbio.2012.03.019
