4r3q
From Proteopedia
Crystal structure of SYCE3
Structural highlights
FunctionSYCE3_MOUSE Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism.[1] [2] Publication Abstract from PubMedThe key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces infertility. Here, we present a crystal structure of the mouse meiosis-specific protein SYCE3, which is a component of the synaptonemal complex central element. Our studies show that functional SYCE3 most likely forms a dimer or higher order oligomer in cells. Furthermore, we demonstrate that the SYCE3 N-helix interacts with the SYCE1 C-helix, which is another central element component. Our results suggest that helical packing may mediate intra- or inter-association of each central element protein component, thereby playing an essential role in forming the synaptonemal complex central elements. Structural insight into the central element assembly of the synaptonemal complex.,Lu J, Gu Y, Feng J, Zhou W, Yang X, Shen Y Sci Rep. 2014 Nov 14;4:7059. doi: 10.1038/srep07059. PMID:25394919[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
| ||||||||||||||||
Categories: Large Structures | Mus musculus | Feng J | Lu J | Shen Y | Yang X | Zhou W
