5imu

Publication Abstract from PubMed

Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; however, its biological function is unknown. Here, the global structure of Rv3899c(184-410), a fragment of Rv3899c, is reported. The structure resembles the shell of a sea snail, and its N- and C-termini form two relatively independent compact domains: an alpha/beta/alpha sandwich folding domain and an alpha-helix bundle domain. There are no reported protein structures for any Rv3899c homologues; this structure provides the first structural glimpse of a new protein family consisting of Rv3899c and its homologues.

Crystal structure of Rv3899c(184-410), a hypothetical protein from Mycobacterium tuberculosis.,Liu Y, Gao Y, Li D, Fleming J, Li H, Bi L Acta Crystallogr F Struct Biol Commun. 2016 Aug;72(Pt 8):642-5. doi:, 10.1107/S2053230X16010943. Epub 2016 Jul 27. PMID:27487929^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.