Structural highlights
Publication Abstract from PubMed
Type I polyketide synthase 13 (Pks13) is involved in the final step of the biosynthesis of mycolic acid in Mycobacterium tuberculosis. Recent articles have reported that Pks13 is an essential enzyme in the mycolic acid biosynthesis pathway, and it has been deeply studied as a drug target in Tuberculosis. We report a high-resolution structure of the acyltransferase (AT) domain of Pks13 at 2.59 A resolution. Structural comparison with the full-length AT domain (PDB code, 3TZW, and 3TZZ) reveals a different orientation of the C-terminal helix and rearrangement of some conserved residues.
Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis.,Yu M, Dou C, Gu Y, Cheng W PeerJ. 2018 May 7;6:e4728. doi: 10.7717/peerj.4728. eCollection 2018. PMID:29761048[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Yu M, Dou C, Gu Y, Cheng W. Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis. PeerJ. 2018 May 7;6:e4728. doi: 10.7717/peerj.4728. eCollection 2018. PMID:29761048 doi:http://dx.doi.org/10.7717/peerj.4728
