Structural highlights
Publication Abstract from PubMed
The 6,6-quinolone scaffolds on which viridicatin-type fungal alkaloids are built are frequently found in metabolites that display useful biological activities. Here we report in vitro and computational analyses leading to the discovery of a hemocyanin-like protein AsqI from the Aspergillus nidulans aspoquinolone biosynthetic pathway that forms viridicatins via a conversion of the cyclopenin-type 6,7-bicyclic system into the viridicatin-type 6,6-bicyclic core through elimination of carbon dioxide and methylamine through methyl isocyanate.
Enzymatic one-step ring contraction for quinolone biosynthesis.,Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K Nat Commun. 2018 Jul 19;9(1):2826. doi: 10.1038/s41467-018-05221-5. PMID:30026518[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K. Enzymatic one-step ring contraction for quinolone biosynthesis. Nat Commun. 2018 Jul 19;9(1):2826. doi: 10.1038/s41467-018-05221-5. PMID:30026518 doi:http://dx.doi.org/10.1038/s41467-018-05221-5
