Structural highlights
Publication Abstract from PubMed
The transcription factor Rv0081 of Mycobacterium tuberculosis controls hypoxic gene expression and acts as a regulatory hub in the latent phase of tuberculosis infection. We report here the crystal structure of Rv0081 at 2.9 A resolution revealing that it belongs to the well-known ArsR/SmtB family proteins. However, unlike other members in this family, Rv0081 has neither a metal binding domain nor does it possess Cys residues, suggesting an alternate mechanism of gene regulation. Our structural and biochemical analyses suggest the molecular basis for the recognition of self-regulatory DNA sequences and a plausible mechanism of regulation of Rv0081 in the latent phase of tuberculosis infection. This article is protected by copyright. All rights reserved.
Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of Mycobacterium tuberculosis.,Kumar A, Phulera S, Rizvi A, Sonawane PJ, Panwar HS, Banerjee S, Sahu A, Mande SC FEBS Lett. 2019 Apr 2. doi: 10.1002/1873-3468.13375. PMID:30941756[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kumar A, Phulera S, Rizvi A, Sonawane PJ, Panwar HS, Banerjee S, Sahu A, Mande SC. Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of Mycobacterium tuberculosis. FEBS Lett. 2019 Apr 2. doi: 10.1002/1873-3468.13375. PMID:30941756 doi:http://dx.doi.org/10.1002/1873-3468.13375
