7bqi
From Proteopedia
Crystal structure of FYCO1 RUN domain
Structural highlights
Disease[FYCO1_HUMAN] Nuclear cataract. The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).[1] Function[FYCO1_HUMAN] May mediate microtubule plus end-directed vesicle transport.[2] Publication Abstract from PubMedFYCO1 is a multidomain adaptor protein that plays an important role in autophagy by mediating the kinesin-dependent microtubule plus-end-directed transport of autophagosomes. FYCO1 contains a RUN domain, which is hypothesized to function as a specific effector for members of the Ras superfamily of small GTPases, but its role has not been well characterized and its interaction partner(s) have not been identified. Here, the crystal structure of the FYCO1 RUN domain was determined at 1.3 A resolution. The overall structure of the FYCO1 RUN domain was similar to those of previously reported RUN domains. Detailed structural comparisons with other RUN domains and docking studies suggested a possible interaction interface of the FYCO1 RUN domain with small GTPases of the Ras superfamily. Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.,Sakurai S, Shimizu T, Ohto U Acta Crystallogr F Struct Biol Commun. 2020 Aug 1;76(Pt 8):326-333. doi:, 10.1107/S2053230X20009012. Epub 2020 Jul 28. PMID:32744243[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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