Structural highlights
Function
GSDM_VITXG Precursor of a pore-forming protein involved in defense against bacteriophages (By similarity). Expression of bGSDM and the neighboring protease gene (Ga0334635_1659) is toxic in E.coli (PubMed:35025633). Cleavage of this precursor by its dedicated protease releases the active moiety (gasdermin bGSDM, N-terminus) which inserts into membranes, forming pores and triggering cell death (By similarity).[UniProtKB:A0A0S2DNG5][UniProtKB:P0DV48][1] Pore-forming protein that causes membrane permeabilization via a pyroptosis-like activity. Makes ring-like pores when released.[UniProtKB:P0DV48]
References
- ↑ Johnson AG, Wein T, Mayer ML, Duncan-Lowey B, Yirmiya E, Oppenheimer-Shaanan Y, Amitai G, Sorek R, Kranzusch PJ. Bacterial gasdermins reveal an ancient mechanism of cell death. Science. 2022 Jan 14;375(6577):221-225. doi: 10.1126/science.abj8432. Epub 2022, Jan 13. PMID:35025633 doi:http://dx.doi.org/10.1126/science.abj8432
