Function
Urokinase receptor or Urokinase plasminogen activator surface receptor or CD87 (uPAR) plays an important role in migration of T cells[1]. uPAR is a GPI-anchored membrane protein. It triggers cell signalling and regulates gene expression within the cell
Disease
uPAR can control the shift between tutor dormancy and proliferation to form metastasis[2]
Relevance
Elevated levels of soluble uPAR are associated with kidney disease[3]. uPAR which is expressed at high levels in malignant tutors is unattractive target for treatment of cancer[4]. uPAR activity in cancer cells may counteract the activity of anticancer drugs[5].
Structural highlights
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