Sodium/glucose cotransporter

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Function

Sodium/glucose cotransporter (SGLT) is responsible for glucose absorption across membranes. SGLT1 and SGLT2 which are expressed in different tissues, have similar active sites but differ in their non-active site structures. SGLT1 is responsible of glucose absorption in the small intestine and SGLT2 in kidney^[1].

Disease

Mutations in SGLT1 cause malabsorption of glucose and galactose^[2].

Relevance

SGLT2 inhibitors aid in hypertension, acute cardiac failure, bradycardia, acute pulmonary oedema, asthma, bronchitis and COPD^[3]..

Structural highlights

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3D structures of sodium/glucose cotransporter