Structural highlights
Publication Abstract from PubMed
The Bacillus subtilis phage varphi29 packaging motor requires prohead RNA for genome encapsidation. The nuclear magnetic resonance structure of the prohead RNA E-loop hairpin, r(5'AUUGAGUU), is presented and compared to predictions from MC-SYM. The prohead RNA E-loop hairpins contain sequences similar to rRNA hairpins. Comparison of predicted and experimentally determined prohead and ribosomal hairpin structures reveals that sequence similarity is a stronger determinant of hairpin structural similarity than grouping similar types of RNA. All the hairpins contain a U-turn motif but differ in the first noncanonical pair and backbone orientation. These structures provide benchmarks for further improvements in RNA structure predictions from sequence.
Nuclear Magnetic Resonance Structure of the Prohead RNA E-Loop Hairpin .,Harris S, Schroeder SJ Biochemistry. 2010 Jul 1. PMID:20550192[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Harris S, Schroeder SJ. Nuclear Magnetic Resonance Structure of the Prohead RNA E-Loop Hairpin . Biochemistry. 2010 Jul 1. PMID:20550192 doi:10.1021/bi100393r
