Structural highlights
6hzn is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
|
| Ligands: | , , , , |
| Gene: | DSE, SART2 (HUMAN) |
| Activity: | Chondroitin-glucuronate 5-epimerase, with EC number 5.1.3.19 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
[DSE_HUMAN] Musculocontractural Ehlers-Danlos syndrome. The disease is caused by mutations affecting the gene represented in this entry.
Function
[DSE_HUMAN] Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.[1]
References
- ↑ Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmstrom A. Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2. J Biol Chem. 2006 Apr 28;281(17):11560-8. doi: 10.1074/jbc.M513373200. Epub 2006 , Feb 27. PMID:16505484 doi:http://dx.doi.org/10.1074/jbc.M513373200
