7z6e

Structural highlights

Function

MRCK_CAEEL Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation (PubMed:19675126). Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation (PubMed:25743393).^{[1] [2]}

References

1. ↑ Lant B, Yu B, Goudreault M, Holmyard D, Knight JD, Xu P, Zhao L, Chin K, Wallace E, Zhen M, Gingras AC, Derry WB. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Nat Commun. 2015 Mar 6;6:6449. PMID:25743393 doi:10.1038/ncomms7449
2. ↑ Gally C, Wissler F, Zahreddine H, Quintin S, Landmann F, Labouesse M. Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles. Development. 2009 Sep;136(18):3109-19. PMID:19675126 doi:10.1242/dev.039412