1e2t

Structural highlights

Function

NHOA_SALTY Catalyzes both the acetyl-CoA-dependent N-acetylation of aromatic amines and the O-acetylation of N-hydroxyarylamines. In vitro, catalyzes the O-acetylation of N-hydroxy-Glu-P-1, and the N-acetylation of isoniazid and 2-aminofluorene.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Arylamine N-acetyltransferase 3D structures

References

1. ↑ Watanabe M, Sofuni T, Nohmi T. Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms. J Biol Chem. 1992 Apr 25;267(12):8429-36 PMID:1569093
2. ↑ Watanabe M, Igarashi T, Kaminuma T, Sofuni T, Nohmi T. N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes. Environ Health Perspect. 1994 Oct;102 Suppl 6(Suppl 6):83-9. PMID:7889864 doi:10.1289/ehp.94102s683