1olt

Structural highlights

Function

HEMN_ECOLI Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. It can use NAD or NADP, but NAD is preferred.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Troup B, Hungerer C, Jahn D. Cloning and characterization of the Escherichia coli hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase. J Bacteriol. 1995 Jun;177(11):3326-31. PMID:7768836
2. ↑ Layer G, Verfurth K, Mahlitz E, Jahn D. Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli. J Biol Chem. 2002 Sep 13;277(37):34136-42. Epub 2002 Jul 11. PMID:12114526 doi:http://dx.doi.org/10.1074/jbc.M205247200