1s3a
From Proteopedia
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| Gene: | NDUFA2 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)
Overview
Subunit B8 from ubiquinone oxidoreductase (complex I) (CI-B8) is one of several nuclear-encoded supernumerary subunits that are not present in bacterial complex I. Its solution structure shows a thioredoxin fold with highest similarities to the human thioredoxin mutant C73S and thioredoxin 2 from Anabeana sp. Interestingly, these proteins contain active sites in the same area, where the disulfide bond of oxidized CI-B8 is located. The redox potential of this disulfide bond is -251.6 mV, comparing well to that of disulfides in other thioredoxin-like proteins. Analysis of the structure reveals a surface area that is exclusively composed of highly conserved residues and thus most likely a subunit interaction site within complex I.
About this Structure
1S3A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The oxidized subunit B8 from human complex I adopts a thioredoxin fold., Brockmann C, Diehl A, Rehbein K, Strauss H, Schmieder P, Korn B, Kuhne R, Oschkinat H, Structure. 2004 Sep;12(9):1645-54. PMID:15341729
Page seeded by OCA on Sun Mar 30 23:36:44 2008
Categories: Homo sapiens | Single protein | Brockmann, C. | Diehl, A. | Kuhne, R. | Oschkinat, H. | Rehbein, K. | Ci-b8 | Complex i | Ndufa2 | Nmr
